Scientists identify new cancer stem cell mechanism

Public release date: 27-Jun-2012
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Contact: Bridget Dempsey
b.dempsey@qmul.ac.uk
44-207-882-7927
Queen Mary, University of London

Scientists at Queen Mary, University of London have uncovered a link between two genes which shows how stem cells could develop into cancer.

The research, published in the online journal PLoS ONE, found a novel mechanism which could be the catalyst for stem cells changing into a tumour.

Dr Ahmad Waseem, a reader in oral dentistry at Queen Mary, University of London who led the research, said: "It was quite an unexpected discovery. We set out to investigate the role of the stem cell gene Keratin K15 which was thought to be a biomarker for normal stem cells.

"Through our research, we discovered there was link between K15 and the notorious cancer gene FOXM1. We found FOXM1 could target K15 to induce cancer formation."

Cancer develops when there is a problem with stem cells; the cells that carry out internal repairs throughout the human body. The loss of stem cell function leads to uncontrolled growth which ultimately develops into a tumour.

The team went through a process where they used extremely sensitive cell and molecular approaches to establish this link.

The study, funded by the Facial Surgery Research Foundation, Saving Faces, paves the way towards identifying new anti-cancer drugs which could be tailored towards cancer stem cells.

Consultant oral and maxillofacial surgeon Professor Iain Hutchison, founder of Saving Faces and co-author on the study, said: "We are excited about this finding as it could lead to more effective cancer drugs being developed to target cancer stem cells and prevent cancer recurrence."

###

'Two mechanisms regulate keratin K15 expression in keratinocytes: role of PKC/AP-1 and FOXM1 mediated signalling' will be published online in the journal PLoS ONE at 17.00 (EST) on 27 June. A link to the article can be found here: http://dx.plos.org/10.1371/journal.pone.0038599

---

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 27-Jun-2012
[ | E-mail | Share ]

Contact: Bridget Dempsey
b.dempsey@qmul.ac.uk
44-207-882-7927
Queen Mary, University of London

Scientists at Queen Mary, University of London have uncovered a link between two genes which shows how stem cells could develop into cancer.

The research, published in the online journal PLoS ONE, found a novel mechanism which could be the catalyst for stem cells changing into a tumour.

Dr Ahmad Waseem, a reader in oral dentistry at Queen Mary, University of London who led the research, said: "It was quite an unexpected discovery. We set out to investigate the role of the stem cell gene Keratin K15 which was thought to be a biomarker for normal stem cells.

"Through our research, we discovered there was link between K15 and the notorious cancer gene FOXM1. We found FOXM1 could target K15 to induce cancer formation."

Cancer develops when there is a problem with stem cells; the cells that carry out internal repairs throughout the human body. The loss of stem cell function leads to uncontrolled growth which ultimately develops into a tumour.

The team went through a process where they used extremely sensitive cell and molecular approaches to establish this link.

The study, funded by the Facial Surgery Research Foundation, Saving Faces, paves the way towards identifying new anti-cancer drugs which could be tailored towards cancer stem cells.

Consultant oral and maxillofacial surgeon Professor Iain Hutchison, founder of Saving Faces and co-author on the study, said: "We are excited about this finding as it could lead to more effective cancer drugs being developed to target cancer stem cells and prevent cancer recurrence."

###

'Two mechanisms regulate keratin K15 expression in keratinocytes: role of PKC/AP-1 and FOXM1 mediated signalling' will be published online in the journal PLoS ONE at 17.00 (EST) on 27 June. A link to the article can be found here: http://dx.plos.org/10.1371/journal.pone.0038599

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2012-06/qmuo-sin062612.php

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Excited hello!

Hello! Not sure what to say other than that. I'm excited to be forum roleplaying again; I run RPGs with some friends every once in a while, but it's been a long time since I've done any serious writing. I messed around a bit in a college course, experimenting for the lulz, but none of it was any good (but it was an easy 4.0 :D). I'm hoping to improve my writing while having fun roleplaying. I guess that's about it? Hello again!

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Exclusive: U.S. expected to grant Iran sanction exceptions to China

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Source: http://news.yahoo.com/exclusive-u-expected-grant-iran-sanction-exceptions-china-170515793.html

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Business ? New Zealand fines Japan Airlines over cargo cartel

Business Jun. 30, 2012 - 06:56AM JST ( )

WELLINGTON (AFP) ?

A New Zealand court on Friday fined Japan Airlines NZ$2.28 million ($1.8 million) after it admitted price fixing on cargo shipments in and out of the country.

The country?s competition watchdog, Commerce Commission New Zealand, said the High Court imposed the fine as part of a long-running case relating to fuel surcharge manipulation.

The commission said Japan Airlines had agreed to admit liability and pay the penalty as part of a pre-trial settlement between the regulator and the carrier, and the court endorsed the deal on Friday.

?The commission is pleased to have settled with another airline,? its lawyer Mary-Anne Borrowdale said in a statement.

Four firms?Japan Airlines, British Airways, Qantas and Luxembourg-based Cargolux International?have so far settled with the commission and paid fines totalling NZ$16.4 million.

The commission?s action alleges airlines colluded on fuel and security surcharges on international cargo flights between 2000 and 2006.

It said a number of airlines?including Air New Zealand, Cathay Pacific, Emirates, Korean Air, Malaysian Airlines, Singapore Airlines and Thai Airways?were contesting the charges.

The case against them is due to go to court in March next year.

? 2012 AFP

Source: http://www.japantoday.com/category/business/view/new-zealand-fines-japan-airlines-over-cargo-cartel

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Do You Still Wear a Watch? [Chatroom]

Watches are, for the most part, a redundant technology. We have digital timekeepers in front of our faces pretty much all the time. And yet, the watch still persists—because of tradition, an appreciation for fashion and design, or straight up novelty. So why do you have a watch on your wrist (if you have one at all)? Image Credit: Uniform Wares More »

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For One Oklahoma Congressional District, Being 95 Percent Conservative Isn?t ?OK?

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Source: http://news.yahoo.com/one-oklahoma-congressional-district-being-95-percent-conservative-170200686.html

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Holocaust survivors partake in beauty pageant in Israel

Menahem Kahana / AFP - Getty Images

Contestants stand during a beauty pageant for Holocaust survivors in the northern Israeli city of Haifa on June 28, 2012.

Fourteen women who lived through the horrors of World War II paraded on stage Thursday night in an unusual pageant, vying for the honor of Israel's first "Miss Holocaust Survivor." The unusual event was hosted by an Israeli group that aids Holocaust survivors. Around 20 women, all in their 80s and 90s, told the audience their life stories. Some 198,000 Holocaust survivors live in Israel today.

Read more about the Pageant

Abir Sultan / EPA

Holocaust survivor Genia Schwartz-Bardt, 89, has her hair made up before the Holocaust Survivor Pageant.

Menahem Kahana / AFP - Getty Images

Pageant contestant Mania Herman, 87, dances during the event.

Sebastian Scheiner / AP

A man sends a kiss to Holocaust survivors participating in the pageant.

Abir Sultan / EPA

Winner Hava Hershkovitz is kissed after her victory.

?Sign up for the msnbc.com Photos Newsletter

Source: http://photoblog.msnbc.msn.com/_news/2012/06/28/12465576-holocaust-survivors-partake-in-beauty-pageant-in-israel

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BRISCOE Nigeria Plc Jobs as Sales Executive,July 2012

BRISCOE Nigeria Plc Jobs as Sales Executive,July 2012

Briscoe Nigeria Plc is set to recruit for Sales Executives in Lagos, Abuja, Rivers, Kano & Delat States. It was incorporated in Nigerian since 1957,? the Company has witnessed tremendous growth and has diversified its area of operations to include the sales and service of motor vehicles and technical equipment. It?s portfolio includes the marketing, sales and service dealership of Toyota vehicles, Volvo cars, Ford Motors, etc in Nigeria.?Continue reading??

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Mo. Gov. Nixon Signs Small-Business Tax Break ? CBS St. Louis

Missouri Gov. Jay Nixon (UPI/Bill Greenblatt)

JEFFERSON CITY, Mo. (AP)- Gov. Jay Nixon has signed into law a measure offering a tax break for some small businesses in Missouri.

Lawmakers in 2011 approved a tax deduction for small businesses based on each job they add. This year?s measure is designed to clarify the types of businesses that can claim the deduction.

Nixon traveled Wednesday to Kansas City and Joplin for bill signing ceremonies. He says helping small businesses grow and create jobs will help Missouri?s economy.

Last week, Nixon?s administration cited the tax break as one of several measures contributing to a projected state budget shortfall. The governor trimmed $15 million from the budget that takes effect Sunday.

(? Copyright 2012 The Associated Press. All Rights Reserved. This material may not be published, broadcast, rewritten or redistributed.)

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'Potentially dangerous' killer escapes London jail

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Teamrecruiter.com Recruiting Front Desk Customer Service ...

Home ? Teamrecruiter.com Hiring Front Desk Customer Service ? Business Centre In Toronto ON Job Title : Front Desk Customer Service - Business Centre
Company : Teamrecruiter.com
City : Toronto
State : Ontario
Country : CA
Location : Toronto, ON
Date : 2012-06-26 16:53:41
Status Active

---

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Project Butter improves Android 4.1's speed to a silky-smooth 60FPS

As part of its unveiling of Android 4.1 Jelly Bean, Google has unveiled Project Butter, a major effort to squash Android's frequent problems with device lag, as well as Systrace to help diagnose performance. Project Butter lets the CPU and graphics run in parallel, rather than crash into each other, and has a big impact on both real and perceived speed: the entire interface runs at 60 frames per second on sufficiently fast hardware. Graphics are now triple-buffered to keep scrolling and transitions humming along, and the processor will swing into full gear the moment you touch the screen to keep input lag to a minimum. Systrace, in the meantime, will help developers stamp out what performance hiccups remain. The tracing tool will be a part of the Jelly Bean SDK, so every coder can get an app running in tip-top shape.

Project Butter improves Android 4.1's speed to a silky-smooth 60FPS originally appeared on Engadget on Wed, 27 Jun 2012 12:48:00 EDT. Please see our terms for use of feeds.

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Fitness and Nutrition Advice from Alison Mowbray ? Zaggora

We?re back with our second round of questions with former Olympic rower Alison Mowbray. Part of her post-rowing career involves running nutrition and exercise workshops, and here she gives us some keen and detailed insight into how to approach food and fitness in a healthy way.

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Alison Mowbray

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1. In your current role as a motivational speaker around issues of health and fitness, what do you find most surprising about people?s attitudes towards these areas?

That so many people consider not doing any exercise at all to be somehow ?normal? and people like me who exercise more days to be a bit strange.? I think it?s the other way round.? Our bodies evolved as hunter/gatherers and we would have been very active just to feed ourselves.? That?s normal for our bodies.

Also, I find it surprising that everyone knows ?5 a Day? but so few people do it. I ask people to write down everything they ate yesterday and it?s not uncommon for people to have eaten no fruit and veg at all. Again, people seem to think eating fruit and veg is just something the government is telling us to do without making any connection to the fact that they are essential to the way our bodies operate. I actually advocate ?8-10 a day? because they are so important. You basically won?t get ill if you eat 8-10 portions of fruit and veg a day?and you won?t be overweight either.

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2. What advice do you have for women who want to become active but find it difficult to make time for exercise every day?

Exercise gives you time back.? And not just a little bit of time.? The most shifting fact I quote around exercise is the results of a long term study with 15,000 men in the States (but I don?t see that it?s any different for women).? Half the group did no exercise at all and the other half just WALKED for 30 MINUTES A DAY.? During the course of the study the group that walked for half an hour a day had a 50% lower mortality rate (they were 50% less likely to die) than the group that did no exercise at all.? If we eat well and exercise then our generation can expect to live well into our 90s, 30 years longer than a few generations ago.? If we look after ourselves we actually have plenty of time in life; if we don?t it may well be quite short.? Getting out for half an hour?s walk a day may well give you 30 extra years to do all that other stuff.? Still think you can?t fit it in?

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3.You say that??What you eat is more important than what you don?t eat.? What for you is essential to eat?

Eat more:

• Fruit
• Vegetables
• Fish
• Nuts & seeds
• Beans & pulses

I can talk a lot about nutrition but actually it doesn?t get any more complicated than that.

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4. Do you think that our culture?s fixation on low-carb or low-calorie diets sends the wrong message, especially to women?

My first healthy eating philosophy is ?you?ve got to eat a lot to eat healthily?. Good food contains essential nutrients that our bodies cannot function without. People very often come up to me (in my self-styled role as Nutrition Guru) and say, ?I?ve been really good today. I?ve ONLY eaten?..? We?ve somehow got ourselves into a situation where we think that eating nothing or as close to nothing as possible is ideal and healthy. And that?s because we focus on weight rather than health. On calories rather than nutrition.

I have a view on low-carb and low-calorie that?s not exactly mainstream.

I do think it?s important to be careful with calories, but ONLY in certain foods.? My guiding principle to myself is that when I?m eating essential foods like fruit, vegetables, fish, nuts & seeds, etc., then I don?t count calories because:

1. Getting the nutrition they contain into my body is the most important thing

2. They generally have low calorie density anyway

3. The calories quoted on the back of the packet for most of these foods are way higher than the energy your body can actually extract from this type of food (they burn the food to work out its calorie content and our body doesn?t do that).

However, when I?m eating more processed carbohydrates?what I call brown/white carbs (bread, pasta, cake, chocolate, crisps, alcohol, etc,)?then I do watch the calories because these foods have very little nutrition and are calorie dense, and because most of the energy is stored as sugar or starch our bodies can?t get to it and the calorie count on the back of the packet is actually pretty accurate. ?I do eat and enjoy all of these but only really good-quality ones and in very small portions (unless I?m exercising a lot)

And it?s the same for ?low-carb?.? People don?t realise that fruit and veg have loads of carbohydrates.? There is as much carbohydrate in an apple as in a slice of bread.? However, there are about 120 things in an apple that do you good and maybe 2 or 3 in bread if it?s very good bread.? I try and get most of my carbohydrates from fruit and vegetables rather than brown/white carbs, but they are not banned.

However, my final controversial point on this is that it?s not ok to be overweight.? It?s not a cultural issue, it?s a health issue.? But again, we shouldn?t focus on the weight.? Being overweight is a SYMPTOM of a poor diet and lack of exercise and this is why it?s linked with a lot of health problems.? 80% of people with type 2 diabetes are overweight.? If people eat healthily and exercise it won?t necessarily make them model skinny (I wish!) but they won?t be unhealthily overweight.

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5. What do you think are the most important nutritional facts for women to keep in mind?

All of the above and THINK POSITIVELY ABOUT FOOD AND OUR BODIES. They are not our enemies.? Our bodies are amazing and will do anything for us without breaking down if we feed them enough nutrients. Healthy, colourful food is so delicious that it?s enjoyable to eat once we get into the habit.

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6. What do you snack on to stay energised?

Apples: I never leave the house without a couple in my bag.? They are a sustainable energy source, full of nutrients, and it?s scientifically proven that people who snack on apples eat fewer calories at meal times.

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Stay tuned for next week?s installment when Alison talks Olympics!

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Read more about Alison at http://www.alisonmowbray.co.uk/.

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