And be sure to read our complete RAZR M review (and just pretend it's pink).
UPDATE: Ah. Right. Verizon also says it'll be available for Valentine's Day, which in hindsight makes a little more sense.
Source: Verizon
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Source: http://feedproxy.google.com/~r/androidcentral/~3/ZMjT_qpoSIs/story01.htm
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Dear Luxury Travel Partner,
Plan your client's summer escape now and soon enough they will be relishing the stunning views of the Amalfi Coast, French Riviera and Costa del Sol from the plush comfort of a private verandah aboard the award-winning Crystal Symphony. On six Mediterranean journeys ranging from 7- to 12-days?including two with Saturday departures?your clients will find themselves exploring ancient ruins in Rome, Ottoman treasures in Istanbul, and iconic beaches in Mykonos. Experience the all-inclusive luxury of Crystal with Book Now Savings of up to $1,200 per person when you book your client's cruise by February 28, 2013 with fares from just $2,495! | Mediterranean Mezes V3215 Rome to Istanbul on Crystal Symphony DATES : Jun. 27 - Jul. 6, 2013 (Days 9) BOOK NOW CRUISE-ONLY FARES FROM : $3,850 New in 2013 for your clients to enjoy are Crystal?s exclusive Boutique Adventures?available only to our guests?offering rare experiences such as cooking lessons with a Michelin-starred Chef or a private concert and lunch at Castle of Calatabiano, both in Taormina. View Voyage Details |
 | Ionian Sea Interlude V3216 Istanbul to Rome on Crystal Symphony DATES : Jul. 6 - 13, 2013 (Days 7) BOOK NOW CRUISE-ONLY FARES FROM : $2,495 Cultured and adventurous, tailor your client's shoreside discovery to their exact wishes...an exclusive evening classical concert at Ephesus, horseback riding on the beaches of Mykonos, or a private motoryacht to the isle of Capri. View Voyage Details |
 | Bounties of the Black Sea V3217 Rome to Istanbul on Crystal Symphony DATES : Jul. 13 - 25, 2013 (Days 12) BOOK NOW CRUISE-ONLY FARES FROM : $5,510 Your clients will join renowned chef, Nobu Matsuhisa, and savor his award-winning fusion creations as they journey to Crimea? discovering an ancient sea more iridescent blue than black, and beautiful lands and mansions once host to Russia's most noble families. View Voyage Details |
 | Empires of Art & Beauty V3218 Istanbul to Rome on Crystal Symphony DATES : Jul. 25 - Aug. 3, 2013 (Days 9) BOOK NOW CRUISE-ONLY FARES FROM : $3,850 Overnight stays in Istanbul and Sorrento allow for added time for your clients to explore places like the Blue Mosque, St. Sophia and the Grand Bazaar in the former capital of Byzantium; or hire a private car to indulge in the treasures of the Amalfi Coast, from Ravello to Positano. View Voyage Details |
 | Riviera Rendezvous V3219 Rome to Barcelona on Crystal Symphony DATES : Aug. 3 - 10, 2013 (Days 7) BOOK NOW CRUISE-ONLY FARES FROM : $3,095 A perfect jet-set holiday...the fountains of Rome, the art of Florence, the cosmopolitan elegance of Portofino and Monte Carlo, and the fabulous wonders of Barcelona, all waiting for your clients to enjoy. View Voyage Details |
 | Coastal Connoisseur V3220 Barcelona to Lisbon on Crystal Symphony DATES : Aug. 10 - 22, 2013 (Days 12) BOOK NOW CRUISE-ONLY FARES FROM : $5,135 After exploring the home of Picasso, Gaudi and Miro, your client can assist with the rehabilitation of marine animals in Barcelona, one of our complimentary voluntourism excursions; or, slip behind the wheel of a Ferrari to explore the French Coast from St-Tropez. View Voyage Details |
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The All Inclusive Crystal Experience? is renowned for its ultra-luxe amenities and services, as well as its unparalleled value. The casually elegant onboard ambience is enhanced with:
Book by February 28, 2013
for the best available fares and let the two highest-rated ships in the world transport your clients to the world?s most spectacular destinations. Let them begin their new story with Crystal today. | Book your client's cruise today via CruiseBuilder; Or call Crystal Cruises? reservation agents from Monday through Friday (6am to 6pm) and Saturday (7am to 3pm) Pacific Standard Time, at our exclusive travel agent number 800-446-6620. |
Source: http://first-time-cruising.blogspot.com/2013/01/explore-europe-aboard-worlds-best.html
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Acceleprise, an accelerator for enterprise startups, has announced eight new companies for its latest class. The companies were chosen from an applicant pool twice the size of the previous class. Acceleprise is also adding a class and increasing the number of companies it accepts. It will now do three classes a year with eight companies in each class. That's up from two sessions a year with six companies in each class.Source: http://feedproxy.google.com/~r/Techcrunch/~3/AafVbA4_23g/
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WASHINGTON (AP) ? First Lady Michelle Obama is wearing a navy Thom Browne coat and dress.
The fabric for the first lady's Inauguration Day attire was developed based on the style of a man's silk tie. The belt she is wearing is from J.Crew and her necklace and earrings were designed by Cathy Waterman. She wore J.Crew shoes, and added J.crew gloves and Reed Krakoff boots for the outside ceremony.
Her daughter Malia is also wearing a J.Crew ensemble. Sasha Obama is wearing a Kate Spade coat and dress.
At the end of the Inaugural festivities, the first lady's outfit and accompanying accessories will go to the National Archives.
Source: http://news.yahoo.com/first-lady-wears-thom-browne-coat-dress-140327878.html
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Illustration by Alex Eben Meyer.
?Is it really true that if you clip your fingernails while your relatives are flying somewhere,? the radio producer asked, ?their plane will crash?? I was being interviewed about my new book, Because I Said So!, which fact-checks 125 classic parental clich?s: breakfast is the most important meal of the day, don?t sit so close to the TV, don?t swim right after you eat. You get the idea. During the commercial break, a producer asked me about this particular bit of wisdom, passed along by her mom.
I took a long look at her; she seemed to be in dead earnest. ?Where does your mom, uh, happen to be from?? I asked as innocently as I could.
?She grew up in Russia.?
I told her I?d never heard that one before?maybe it was more of a Slavic thing. I wasn?t surprised at all to find out that Mom, in this case, had been raised outside the United States. In writing the book, I?d spent the past two years soliciting parental nags from friends, acquaintances, and Internet strangers, and I?d learned very quickly that these bits of folklore tend to be extremely culture-specific. A classic Mexican momism might bear no more resemblance to a Scandinavian one than huevos rancheros do to lutefisk.
In China, for example, it?s widely believed that sitting on a seat recently warmed by someone else?s behind can give you hemorrhoids. The Brits, on the other hand, attribute hemorrhoids to sitting on cold surfaces. But sitting on that same cold concrete would lead to a different lecture from a Ukrainian mom: She?d be sure it would make you sterile.
Some Peruvians are told that lingering too long in front of the fridge can cause cancer. In the Czech Republic, everyone knows that drinking water after eating fruit leads to painful bloating. Filipino kids can?t wear red when it?s stormy out, since that would attract lightning. Germans and Austrians live in mortal fear of drafts, which get blamed for everything from pneumonia to blocked arteries, so summertime commuters routinely swelter on 90-degree trains and buses rather than cracking a window through which a cooling?but lethal!?breeze might pass.
In South Korea, however, the concern about ventilation is exactly the opposite. Koreans will only use electric fans if a window is cracked, because leaving a fan on in an enclosed room, it?s almost universally believed, can be fatal. The mechanism behind the threat is a little vague: Sometimes it?s said to be a lack of oxygen that kills you, sometimes it?s a chill. But either way, you won?t care. You?ll be dead.
I actually grew up as a child in Seoul, South Korea, and fans were no laughing matter. Everyone took the Great Fan Menace for granted and had a hard time believing that other cultures were ignorant of it. An apartment of Americans I knew teased their lone Korean roommate by going to bed one summer night in an enclosed room with six electric fans turned on. He pleaded with them not to throw their lives away and slept in the hallway. When, in the morning, all three had survived the ordeal, the Korean roommate was still not convinced. Obviously, he said, they had been playing a practical joke on him and had cracked a window as soon as he was out of the room.
Source: http://feeds.slate.com/click.phdo?i=bd8daf2a40a1c76a2273760ef7a693e8
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I?m one of those people who order the exact same thing every time I go to a restaurant. You might say I?m boring, but I say, ?I know what I like?. ?Now that menu item varies from place to place, but more often than not, it?s a salad.
Some restaurants make dang good salads, y?all.
But, those salads get ?spensive! Mama doesn?t like spending much money (mostly because she doesn?t have much to spend).
So I thought I?d try those Lean Cuisine Salad Additions that I keep seeing, since one of the four varieties is a Southwest-Style and mimics my absolute favorite restaurant salad evah.
Walmart had two of the four varieties, one of which was the one I wanted, and they were priced at $2.50.
Totally fair, right?
Yeah, but since I always hunt down coupons when trying new products I?m not sure I like yet, I had a $1 off two coupon to add to that. (Get one here.)
Snagging two meals for $4?
Mama did right by mama.
One thing to note: this is a BYOL situation, folks. So bring your own lettuce to the party.?I always have bagged romaine lettuce on hand, so I didn?t have to spend any extra for that.
I was so happy to see that the salad contents were in separate pouches, giving me the option to leave something off if I wanted.
The directions said to thaw the dressing in a cup of room temperature water, then heat the chicken & vegetable steam pouch in the microwave for 2 1/2 minutes and let sit for 1 more. Easy and quick!
Next, I just added the whole lotta to my bed of romaine and voil?.
Lunchtime!
Looks good, doesn?t it?
Sooooo, did Lean Cuisine Salad Additions make a great substitution for a restaurant salad?
Mostly, yes!
In terms of value, it won by far. Each salad only cost me $2, and even if I added in the lettuce expense, it was still way less than the price of its restaurant rival. Plus the?amount of salad dressing and tortilla strips was super generous.
Naturally it didn?t taste exactly like a restaurant salad. How could it? But I liked it. I?d even say I liked it a lot. I especially loved the corn and black bean combo. Yummy!
The only suggestion I would make to Lean Cuisine would be about the peppers. They were overdone and too soft, so when I first bit into them, I thought I had bitten into a piece of meat fat. But nope, it was just the squishy peppers.
Overall, the convenience of having a substitute salad in my freezer for whenever the mood strikes me completely won me over. I like dining out, but I like saving money more. Also, I?m a total salad person, but I hate prepping all the ingredients.
I?ll definitely be buying more of these. (Plus, I want to try the other varieties.)
?
?
I am a member of the Collective Bias? ?Social Fabric? Community. ?This shop has been compensated as part of a social shopper insights study for Collective Bias? ?and NESTLE #CBias #SocialFabric. You can see the details of my actual shopping trip within my Google + story, and all opinions within this post are my own.
Source: http://www.anutinanutshell.com/2013/01/lean-cuisine-salad-additions/
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Jan. 20, 2013 ? A research team led by the La Jolla Institute for Allergy & Immunology has discovered the mechanism that enables CD4 helper T cells to assume the more aggressive role of killer T cells in mounting an immune attack against viruses, cancerous tumors and other damaged or infected cells. The finding, made in collaboration with researchers from the RIKEN Institute in Japan, could enable the development of more potent drugs for AIDS, cancer and many other diseases based on using this mechanism to trigger larger armies of killer T cells against infected or damaged cells.
CD4 helper T cells, which normally assist other cells of the immune system during an infection, and CD8 killer T cells, which directly attack and eliminate infected cells, are two of the body's most important immune cells for defending against diseases. Earlier research studies have shown that helper T cells can become killer cells in some instances. However, the specific mechanism of action that allowed this to occur was not known until now.
"We have identified the molecular switch that enables CD4 T cells to override their programming as helper cells and transform into cytolytic (killer) cells," said La Jolla Institute scientist and study co-leader Hilde Cheroutre, Ph.D. "Our team also showed that these transformed helper T cells represent a separate and distinct population of cells. They are not a subset of TH-1 helper cells as previously thought."
Jay A. Berzofsky, M.D., Ph.D., chief of the Vaccine Branch at the National Cancer Institute's Center for Cancer Research, called the finding "a major advance" that provides new understanding about the cell's lineage and basic mechanisms. Dr. Berzofsky was among the researchers whose work in the 1980s first demonstrated that helper cells could convert to killer cells. "Understanding how these cells derive and what causes them to switch from helper T cells to cytolytic T cells is an important step to learning how to manipulate them in disease," he said, noting it could lead to novel approaches "either to turn these cells off in autoimmune disease or turn them on in infectious diseases."
He added that the finding could also have important implications in cancer. "We need all of the cytolytic machinery that we can get to try to destroy cancers," he said. "If we can learn to turn them on, I think it's reasonable to believe that these cytolytic T cells can play an important role in controlling cancer."
The findings were published January 20 in Nature Immunology in a paper entitled "Transcriptional reprogramming of mature CD4 helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes." Dr. Cheroutre is co-senior author on the study together with Dr. Ichiro Taniuchi of the RIKEN Research Center for Allergy and Immunology in Yokohama, Kanagawa, Japan. First authors on the paper are: Mohammad Mushtaq Husain, Ph.D., of the La Jolla Institute; Daniel Mucida, Ph.D., formerly of the La Jolla Institute, now at Rockefeller University; Femke van Wijk, Ph.D., formerly of the La Jolla Institute, now at the University Medical Center Utrecht, The Netherlands, and Sawako Muroi, of the RIKEN Institute.
In the study, the researchers found that a certain transcription factor, which are molecules in the cell nucleus that control the activity of cells, continually suppresses the killer T cell lineage in helper T cells. Using mice, the team showed that turning off this transcription factor (ThPOK) enabled the helper cells in the body's peripheral areas, like the blood, spleen and the intestine, to override their original programming and to become killer T cells. "While our work focused on the intestines, we found that helper T cells in all tissues of the body have the potential to become killer cells in response to recognition of viral, tumor or other antigens in the context of cytokines such as IL-15," said Dr. Cheroutre.
Jonathan Braun, M.D., chair of the Department of Pathology and Laboratory Medicine at UCLA's David Geffen School of Medicine, praised the study as laying the groundwork for using T helper cells in a much more aggressive manner. "Helper T cells are mainly understood for their role in regulating other immune cells," he said. "This work reveals how they themselves can be triggered to become the action cells in the immune response. This opens new possibilities for how to manipulate them therapeutically in disease."
Dr. Cheroutre said the transformation of CD 4 helper T cells into killer cells already occurs in the body naturally. "Our finding could help to explain a number of occurrences that we haven't really understood up to this point, such as why some people can be chronically infected with HIV without developing AIDS." In these instances, Dr. Cheroutre is convinced that CD4 helper T cells must be taking over the role of killer cells after the CD8 T cells become exhausted. "It's like the helper cells can come in as reinforcements to keep the virus under control. If we can develop ways to artificially trigger that process, we may be able to significantly help people with HIV and other chronic infections."
While scientists would want to trigger a larger army of virus-specific killer cells in the case of infections, the opposite would be true in inflammation-fueled autoimmune diseases, like rheumatoid arthritis or multiple sclerosis, said Dr. Cheroutre. "The CD4 T cells are the bad wolves in inflammatory diseases because they often trigger more pro-inflammatory cells which worsen these conditions," she said. "With this knowledge, we may be able to prevent that by coaxing the CD4 killer cells to become regulatory cells instead, which is another one of their potential functions. In regulatory mode, the CD4 T cells suppress the immune system. This suppression reduces inflammatory cells, which is what we want to do in autoimmune diseases."
However in cancer, the CD4 T cell's regulatory function becomes problematic because they inhibit the killer T cells from destroying cancerous cells. This is because of their built-in mechanism to keep T cells from attacking the body's own cells, said Dr. Cheroutre. "Cancer cells develop from our own cells and only look a little different from healthy cells," she explained. "The killer T cells can sense that they are different and decide to eliminate them. However, the CD4 regulatory T cells frequently suppress the killer T cells and prevent them from destroying the cancerous cells. This is often how cancer cells can escape the immune system's normal action of stamping out bad cells."
Dr. Cheroutre said she believes it may be possible, using the newly discovered mechanism, to turn the CD4 regulatory T cells into killer cells that would aid, rather than block, the immune system's attack on cancerous cells.
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Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/giCX8Rpjye8/130120145823.htm
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