Source: http://www.thehollywoodgossip.com/2013/05/sex-superbug-gonorrhea-strain-as-deadly-as-aids/
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Tuesday, May 7, 2013
Friday, May 3, 2013
Saturday, April 27, 2013
New charges - and maybe a new home - coming for Maine hermit
By Tracy Connor, Staff Writer, NBC News
The Maine "hermit" wants to get back to the land, but first he'll have to deal with up to a dozen new burglary charges.
When he was arrested for a break-in earlier this month, Christopher Knight, 47, amazed the public with his story of spending 27 years in the woods with no human contact, surviving on whatever he could steal from surrounding camps.
Kennebec County District Attorney Maeghan Maloney said Friday that police are combing through burglary reports from the last six years ? the statute of limitations ? and matching them to Knight's confession of hundreds of thefts.
Kennebec County Sheriff's Office
Christopher Knight was arrested on April 4, 2013, while stealing food from a camp in Rome, Maine.
In the next two weeks, Knight will be hit with a new round of charges. Maloney, though, said no one is anxious to throw the book at the remorseful recluse, who wants to pay back his victims.
"Christopher Knight has a bank account and all money put into that bank account will go first to pay restitution and any more left over goes to him," Maloney said.
"He has said it is his dream to have enough to buy his own piece of land."
Knight, who told police he simply walked into the forest when he was 19 and never looked back, built a makeshift camp for himself in Rome that has since been dismantled.
There were rumors of a "North Pond Hermit" who was breaking into camps that ring the pond, but no one saw him until Knight tripped an alarm three weeks ago and was arrested.
He was charged with one burglary and then a second. His bail was raised to $250,000 then lowered to $25,000, with the restriction that it couldn't be posted by a third party, to stop someone from taking advantage of him.
While he's been held in the county jail, where he's awaiting a mental health evaluation, his only complaint has been "the television is too loud," Maloney said.
He mainly speaks to his lawyer, who declined to speak about him, and the investigating officer, Trooper Diane Perkins-Vance. The trooper has befriended Knight, visiting when she's off the clock.
"He told me it's not that he dislikes people, he just doesn?t want to be around people," Perkins-Vance told WCSH.
Knight's apparent restraint in stealing only what he needed and his apologies to the victims have made him a sympathetic figure. He even got a marriage proposal, and there's talk of a book deal.
Maloney said the suspect lucked out by getting Perkins-Vance as an investigator and herself as the prosecutor.
"[She] hasn?t viewed this case as 'I want to lock him up and throw away the key," the DA said, "And I ran on a platform of being smart on crime and differentiating between crimes where a person can be rehabilitated and ones where they cannot."
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Friday, April 26, 2013
JCPenney Has Chosen A New Ad Agency [THE BRIEF] - Business ...
JCPenney ? under the purview of Sergio Zyman ? has chosen Y&R New York as its new lead agency. The troubled retailer parted ways with Saatchi & Saatchi a couple of years ago to work with Mother, New York, and Peterson Milla Hooks until now.
Danone Groupe has put its $1.47 billion global media business into review. Havas Worldwide is the incumbent.
Actors in commercials will get a 6% pay raise, Ad Age says.
Ad industry gets blasted in Senate for dragging feet on Do Not Track.
P&G will hike its marketing spending this year.
Barton F. Graph 9000 used a banner-towing plane to announce three creative hires.
Reuters does a deep dive on Amazon's new ad network.
Urban Outfitters, one of the earliest adopters of Vine, is producing a whole campaign around the Twitter video product.
Previously on Business Insider:
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Source: http://www.businessinsider.com/jcpenney-has-chosen-a-new-ad-agency-the-brief-2013-4
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Boston bombing suspect moved to prison from hospital: officials
(Ends first round) NEW YORK, April 25 (Reuters) - Selections in the first roundof the 2013 NFL Draft at Radio City Music Hall on Thursday (picknumber, NFL team, player, position, college): 1-Kansas City, Eric Fisher, offensive tackle, Central Michigan 2-Jacksonville, Luke Joeckel, offensive tackle, Texas A&M 3-Miami (from Oakland), Dion Jordan, defensive tackle, Oregon 4-Philadelphia, Lane Johnson, offensive tackle, Oklahoma 5-Detroit, Ezekiel Ansah, defensive end, Brigham Young 6-Cleveland, Barkevious Mingo, linebacker, LSU 7-Arizona, Jonathan Cooper, guard, North Carolina 8-St. ...
Source: http://news.yahoo.com/boston-suspects-had-spontaneous-bomb-plan-york-013726316--sector.html
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Novel therapeutic approaches may cure chronic HBV infection
Apr. 25, 2013 ? Exciting new data presented today at the International Liver Congress? 2013 include results from early in vitro and in vivo studies targeting covalently closed circular DNA (cccDNA), which may form the basis of a cure for chronic hepatitis B virus (HBV) infection.
HBV cccDNA is organized into mini-chromosomes within the nucleus of infected cells by histone and non-histone proteins. Despite the availability of efficient therapies against HBV, long-term persistence of cccDNA necessitates life-long treatments to suppress the virus. The following three experimental studies demonstrate effective HBV-cccDNA targeting/depletion using novel therapeutic approaches which offer the potential of a cure.
Liver regeneration induces strong reduction of viral replication and cccDNA levels, but not complete cccDNA eradication; without antiviral treatment, de novo HBV infection can be re-established.
Key findings of research in HBV-infected human hepatocytes using the uPA/SCID chimeric mouse system show that liver regeneration induces strong reduction of viral replication and cccDNA levels, with rapid formation of cccDNA-free hepatocytes. However, because complete cccDNA eradication is not achieved, in the absence of antiviral treatment, de novo HBV infection could be re-established in quiescent (non-dividing) human hepatocytes. This suggests that induction of hepatocyte turn-over together with antiviral drugs inducing viral suppression, such as nucleoside analogues and IFN, or blocking cell entry, may accelerate the clearance of the viral minichromosome.
Targeting epigenetic control of nuclear cccDNA minichromosome to suppress HBV transcription and replication may form basis for other therapeutic approaches to curing chronic HBV infection.
In the infected liver cell the rate of replication of HBV is regulated by the acetylation or methylation of histone proteins which surround the cccDNA minichromosome -- so called epigenetic regulation. In a separate innovative study, the suppression of HBV transcription and replication by small molecules that target the epigenetic control of nuclear cccDNA minichromosome was investigated. The different classes of small molecules studied included: Class I, II and III histone deacetylase inhibitors (HDACi); p300 and PCAF histone acetyltransferases (HAT) inhibitors; hSirt1 activators; JMJD3 histone demethylase inhibitors.
The combined inhibition of p300 and PCAF HATs resulted in an evident reduction of HBV replication which mirrored the decrease of pgRNA transcription. The hSirt1/2 activator MC2791 and the JMJD3 inhibitor MC3119, albeit with different efficiency, inhibited both HBV replication and cccDNA transcription. Results represent a proof of concept that activation of hSirt1 and Ezh2 (through the inhibition of its functional antagonist JMJD3) by small molecules can induce an active epigenetic suppression of HBV cccDNA minichromosome similar to that observed with IFN?, and lead to persistent cccDNA silencing.
Lymphtoxin beta receptor (LTbR) agonisation represents basis for novel alternative therapeutic approach to curing chronic HBV infection.
The final study demonstrated that stimulating the lymphtoxin beta receptor (LTbR) provides an effective, long lasting and non-cytopathic mechanism for achieving effective HBV-cccDNA depletion in infected hepatocytes. Cell culture models including HBV-infected HepaRG cells and primary human hepatocytes were used to test the effect of antibodies stimulating human LTbR (BS1 or CBE11). Results show that a strong and dose-dependent anti-HBV effect was achieved by activation of the LTbR. All HBV replication markers were decreased with this treatment, including cccDNA in cells where HBV infection was already established.
Hepatitis B is the most prevalent cause of chronic viral hepatitis and a major global health problem. Prof. Fabien Zoulim, EASL Educational Councillor commented on the exciting new data: "In chronic hepatitis B infection, the viral genome forms a stable minichromosome -- the covalently closed circular DNA (cccDNA) -- which can persist throughout the lifespan of the hepatocyte."
"Current treatments focus on suppression of HBV and discovery of compounds directly targeting cccDNA has been one of the major challenges to curing HBV infection; but these preliminary data show novel therapeutic approaches can be applied to successfully target cccDNA with the long-term aspiration of finding a cure" added Prof. Fabien Zoulim.
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The above story is reprinted from materials provided by European Association for the Study of the Liver, via EurekAlert!, a service of AAAS.
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Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/oorJAU_URNI/130425091612.htm
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This Beginner's DSLR Is Your Deal of the Day
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Source: http://feeds.gawker.com/~r/gizmodo/full/~3/FiK582uwfI4/this-beginners-dslr-is-your-deal-of-the-day
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